期刊
EMERGING INFECTIOUS DISEASES
卷 22, 期 4, 页码 590-597出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2204.151485
关键词
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资金
- National Institute for Health Research Health Protection Research Unit in Gastrointestinal Infections
- National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections at the University of Liverpool
- University of East Anglia
- University of Oxford
- Institute of Food Research
- Public Health England (PHE)
We evaluated clinical Shiga toxin producing Escherichia coli O157 infections in England and Wales during 1983-2012 to describe changes in microbiological and surveillance methods. A strain replacement event was captured; phage type (PT) 2 decreased to account for just 3% of cases by 2012, whereas PT8 and PT21/28 strains concurrently emerged, constituting almost two thirds of cases by 2012. Despite interventions to control and reduce transmission, incidence remained constant. However, sources of infection changed over time; outbreaks caused by contaminated meat and milk declined, suggesting that interventions aimed at reducing meat cross-contamination were effective. Petting farm and school and nursery outbreaks increased, suggesting the emergence of other modes of transmission and potentially contributing to the sustained incidence over time. Studies assessing interventions and consideration of policies and guidance should be undertaken to reduce Shiga toxin producing E. coli O157 infections in England and Wales in line with the latest epidemiologic findings.
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