期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 496, 期 2, 页码 515-522出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2018.01.089
关键词
Curcumin; Cortical neurons; Oxygen and glucose deprivation/reoxygenation; Flotillin-1; Mitogen-activated protein kinase
资金
- National Natural Science Foundation of China [81503551, 81603595]
- Natural Science Foundation of Shanghai [15ZR1442300]
- Shanghai Pujiang Program [17PJD039]
- Xinglin Program of Shanghai University of TCM
In this study, we provided evidence that curcumin could be a promising therapeutic agent for ischemic stroke by activating neuroprotective signaling pathways. Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor. Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition. Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway. (C) 2018 Elsevier Inc. All rights reserved.
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