期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 495, 期 1, 页码 1383-1388出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.11.163
关键词
SREBP1; NF-kappa B; Clear cell renal cell carcinoma; Lipid metabolism; Lipid desaturation
Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancers, is an incurable and lethal disease. Although great progresses have been made in understanding the mechanism of ccRCC, metabolic reprogramming in ccRCC remains largely unclear. Here, we showed that lipid desatutation might be a metabolic hallmark of ccRCC. We demonstrated sterol regulatory element-binding protein 1 (SREBP1) is overexpressed in ccRCC cell lines and positively correlated with NF-kappa B activation. Further, SREBP1 is required for lipid desaturation and cell growth in ccRCC. Mechanistically, we demonstrated that SREBP1-driven lipid desaturation promotes NF-kappa B activation. Our finding reveals a crucial roles for SREBP1 in lipid desaturation of ccRCC through regulation of NF-kappa B signaling, which provides not only new insights in regulatory mode of NF-kappa B signaling but also a novel target for potential metabolic therapies. (C) 2017 Published by Elsevier Inc.
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