期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 500, 期 1, 页码 26-34出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.06.190
关键词
Mitochondrial apoptosis; Retrotranslocation; BCL-2 proteins; BH3-only proteins
资金
- Emmy Noether program [ED 190/2-1]
- Heisenberg program [ED 190/4-1]
- German Research Council (Deutsche Forschungsgemeinschaft, DFG) [Sonderforschungsbereich 746]
- Else Kroner-Fresenius-Stiftung [2016_A57]
- Wilhelm Sander-Stiftung [2017.007.1]
- Excellence Initiative of the German Federal and State Governments [EXC-294]
Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. The proapoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death by permeabilizing the outer mitochondrial membrane (OMM) and subsequent initiation of the caspase cascade. Therefore, the activities of BAX and BAK are precisely controlled by a complex network of proteins inside and outside the BCL-2 family. Cells survive by constant control of dynamic translocation and retrotranslocation of BAX and BAK to the mitochondria and back into the cytosol. Recent insights into BAX/BAK shuttling, BCL-2 protein interactions, the role of BH3-only proteins in apoptosis signaling and the active BAX complex set the stage for the development of novel strategies in cancer therapy and the analysis of cellular predisposition to apoptosis. (C) 2017 Elsevier Inc. All rights reserved.
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