期刊
ACTA NATURAE
卷 8, 期 2, 页码 75-78出版社
RUSSIAN FEDERATION AGENCY SCIENCE & INNOVATION
DOI: 10.32607/20758251-2016-8-2-75-78
关键词
heat shock; DNA repair; DNA damage; DNA replication; topoisomerase
资金
- Russian Science Foundation [14-24-00022]
- Russian Science Foundation [14-24-00022] Funding Source: Russian Science Foundation
Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.
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