期刊
FEBS LETTERS
卷 589, 期 20, 页码 2914-2922出版社
WILEY
DOI: 10.1016/j.febslet.2015.05.016
关键词
Nucleosome structure; Histone; Chromatin structure
资金
- NIH [R01GM052426, T32 GM068411]
The nucleosomal subunit organization of chromatin provides a multitude of functions. Nucleosomes elicit an initial similar to 7-fold linear compaction of genomic DNA. They provide a critical mechanism for stable repression of genes and other DNA-dependent activities by restricting binding of trans-acting factors to cognate DNA sequences. Conversely they are engineered to be nearly meta-stable and disassembled (and reassembled) in a facile manner to allow rapid access to the underlying DNA during processes such as transcription, replication and DNA repair. Nucleosomes protect the genome from DNA damaging agents and provide a lattice onto which a myriad of epigenetic signals are deposited. Moreover, vast strings of nucleosomes provide a framework for assembly of the chromatin fiber and higher-order chromatin structures. Thus, in order to provide a foundation for understanding these functions, we present a review of the basic elements of nucleosome structure and stability, including the association of linker histones. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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