期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 31, 期 2, 页码 126-134出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2018.01.002
关键词
Good manufacturing practices; Manufacturing; CAR-T cells
类别
资金
- Cancer Prevention and Research Institute of Texas [3300017409]
The clinical success achieved using CD19-directed CAR-T cells has stimulated many academic institutions to explore the feasibility of manufacturing these, and other CAR-T cells, in-house. This article reviews the issues that must be addressed in order to achieve this goal. It includes the manufacturing infrastructure, the regulatory environment, practical aspects of production, and the costs involved. (C) 2018 Elsevier Ltd. All rights reserved.
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