期刊
FEBS LETTERS
卷 589, 期 24, 页码 3702-3713出版社
WILEY
DOI: 10.1016/j.febslet.2015.10.021
关键词
Mitochondria; Parkinson's disease; Dopamine; Bioenergetics; Neurodegeneration
资金
- Betty Brown's Family
- Joan and David Traitel Family Trust
- NIH [1RO1NS091902]
- Larry L. Hillblom Foundation Fellowship
Mitochondria are undoubtedly changed in Parkinson's disease (PD), and mitochondrial functions are disrupted in genetic and pharmacologic models of PD. However, many of these changes might not truly drive neurodegeneration. PD is defined by the particular susceptibility of nigrostriatal dopamine (DA) neurons, but little is understood about the mitochondria in these cells. Here, we critically review the evidence that mitochondrial stressors cause PD. We then consider how changes in the intrinsic function of mitochondria and in their mass, distribution, and dynamics might synergize with an increased need for mitochondria and produce PD, and the importance of understanding how mitochondria contribute to its pathogenesis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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