期刊
FEBS LETTERS
卷 589, 期 19, 页码 2464-2476出版社
WILEY
DOI: 10.1016/j.febslet.2015.07.024
关键词
Intermediate filament; Intrinsically disordered protein; Cytoskeleton; Polymer brush; Self-assembly
资金
- Israeli Science Foundation [571/11]
- European Community's Seventh Frame Work Programme [CIG - 293402]
- DKFZ-MOST Cancer Research Grant [Ca 160]
- Tel Aviv University's Center for Nanoscience and Nanotechnology
- Abramson Center for Medical Physics
- Marian Gertner Institute for Medical Nanosystems
- Sackler Institute for Biophysics
Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile, tunable network of self-assembled proteins. IF proteins contain three distinct domains: an alpha-helical structured rod domain, flanked by intrinsically disordered head and tail domains. Recent studies demonstrated the functional importance of the disordered domains, which differ in length and amino-acid sequence among the 70 different human IF genes. Here, we investigate the biophysical properties of the disordered domains, and review recent findings on the interactions between them. Our analysis highlights key components governing IF functional roles in the cytoskeleton, where the intrinsically disordered domains dictate protein-protein interactions, supramolecular assembly, and macro-scale order. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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