期刊
FEBS LETTERS
卷 589, 期 17, 页码 2218-2223出版社
WILEY
DOI: 10.1016/j.febslet.2015.06.031
关键词
Non-small cell lung cancer; microRNA; miR-410; Bromodomain-contajning protein 7
miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410. MiR-410-mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR-410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR-410 in NSCLC. Our data provided new knowledge regarding the role of miR-410 in the lung cancer progression. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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