期刊
EFORT OPEN REVIEWS
卷 1, 期 4, 页码 89-99出版社
BIOSCIENTIFICA LTD
DOI: 10.1302/2058-5241.1.000037
关键词
orthopaedic implant infections; osteomyelitis; biofilm; treatment; novel antimicrobials; immunisation; anti-biofilm agents
类别
资金
- COST Action [TD1305]
- EU, FP7-HEALTH-2011 [278890]
- BALI - Biofilm Alliance
- Fund for Scientific Research - Flanders (FWO-Vlaanderen)
- Institute for the Promotion of Innovation through Science & Technology in Flanders (IWT, SBO program)
- Belgian Science Policy Office
- Swiss National Foundation [PZ00P3_142403I]
Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern trauma and orthopaedic surgery. Despite best practice in medical and surgical management, neither prophylaxis nor treatment of ODRI is effective in all cases, leading to infections that negatively impact clinical outcome and significantly increase healthcare expenditure. The following review summarises the microbiological profile of modern ODRI, the impact antibiotic resistance has on treatment outcomes, and some of the principles and weaknesses of the current systemic and local antibiotic delivery strategies. The emerging novel strategies aimed at preventing or treating ODRI will be reviewed. Particular attention will be paid to the potential for clinical impact in the coming decades, when such interventions are likely to be critically important. The review focuses on this problem from an interdisciplinary perspective, including basic science innovations and best practice in infectious disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据