期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 14, 期 -, 页码 484-498出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.14.34
关键词
carbohydrate; cholera; multivalency; toxin
资金
- European Union [746421]
- Marie Curie Actions (MSCA) [746421] Funding Source: Marie Curie Actions (MSCA)
Cholera is a diarrheal disease caused by a protein toxin released by Vibrio cholera in the host's intestine. The toxin enters intestinal epithelial cells after binding to specific carbohydrates on the cell surface. Over recent years, considerable effort has been invested in developing inhibitors of toxin adhesion that mimic the carbohydrate ligand, with particular emphasis on exploiting the multivalency of the toxin to enhance activity. In this review we introduce the structural features of the toxin that have guided the design of diverse inhibitors and summarise recent developments in the field.
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