期刊
BEHAVIOURAL PROCESSES
卷 149, 期 -, 页码 35-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.beproc.2018.01.020
关键词
Fear conditioning; Alarm substance; Conditioned place aversion; Psychiatric disorders; Zebrafish
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Federal University of Santa Maria (UFSM)
- Fundo de Incentivo a Pesquisa (FIPE/UFSM)
- CAPES
- CNPq
Anxiety, trauma- and stressor-related disorders are severe psychiatric conditions that affect human population worldwide. Given their genetic tractability, evolutionarily conserved neurotransmitter systems, and extensive behavioral repertoire, zebrafish have become an emergent model organism in translational neuroscience. Here, we investigate whether a single exposure to conspecific alarm substance (CAS) produces fear conditioning in zebrafish using a conditioned place aversion (CPA) paradigm, as well as the persistence of aversive responses at different time intervals. While CAS elicited freezing and erratic movements at conditioning phase, zebrafish showed a robust avoidance for the CAS-paired compartment and increased risk assessment up to 7 days post conditioning. Additionally, we observed the existence of two behavioral phenotypes (high- and low-avoider fish) that present different fear-like responses at conditioning phase and evasion of the conditioning side at post conditioning trials. Collectively, we show a prolonged conditioned place aversion in zebrafish after a single CAS conditioning session, reinforcing the use of fear conditioning protocols as valuable strategies for modeling psychiatric disorders-related phenotypes in zebrafish.
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