期刊
FEBS LETTERS
卷 589, 期 19, 页码 2578-2589出版社
WILEY
DOI: 10.1016/j.febslet.2015.08.028
关键词
ATPases Associated with diverse cellular Activities; p47; UFD1-NPL4; UBXD1; Inclusion Body Myopathy with Pagets disease of the bone and Fronto-temporal; Dementia
资金
- Deutsche Forschungsgemeinschaft [BU 951/3-2, HA 3405/3-1]
- Rudolf Virchow Center for Experimental Biomedicine [FZ 82]
p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though p97 is involved in highly diverse cellular pathways and processes, it exhibits hardly any substrate specificity on its own. Instead, it relies on a large number of regulatory cofactors controlling substrate specificity and turnover. The complexity as well as temporal and spatial regulation of the interactions between p97 and its cofactors is only beginning to be understood at the molecular level. Here, we give an overview on the structural framework of p97 interactions with its cofactors, the emerging principles underlying the assembly of complexes with different cofactors, and the pathogenic effects of disease-associated p97 mutations on cofactor binding. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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