期刊
FEBS LETTERS
卷 589, 期 15, 页码 1911-1919出版社
WILEY
DOI: 10.1016/j.febslet.2015.05.056
关键词
miR-362-5p; Motility; Proliferation; Neuroblastoma; Phosphatidylinositol 3-kinase
资金
- Natural Science Foundation of Guangdong Province [S2013010015998]
miR-362-5p is down-regulated in high-risk neuroblastoma and can function as a tumor suppressor. However, its role remains poorly understood. We show that miR-362-5p is down-regulated in metastatic neuroblastoma compared with primary neuroblastoma. Overexpression of miR-362-5p inhibits cell proliferation, migration and invasion of neuroblastoma cells in vitro and suppresses tumor growth of neuroblastoma in vivo. Phosphatidylinositol 3-kinase (PI3K)-C2 beta is a target of miR-362-5p. Knockdown of PI3K-C2 beta by siRNA had a similar effect to overexpression of miR-362-5p on SH-SY5Y cells. Overexpression of PI3K-C2 beta partially reversed tumor-suppressive effects of miR-362-5p. We suggest that miR-362-5p suppresses neuroblastoma cell growth and motility, partially by targeting PI3K-C2 beta. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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