期刊
BEHAVIOURAL BRAIN RESEARCH
卷 359, 期 -, 页码 942-949出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2018.06.015
关键词
Neuropathic pain; Maternal separation; Stress; Microglia
资金
- MEXT [16H03303, 16K13505, 17H06053]
- Nakatomi Foundation
- Tokyo Seikagaku Foundation
- Takeda Science Foundation
- Smoking Research Foundation, Japan
- Program for Promotion of Fundamental Studies in Health Sciences from the National Institute of Biomedical Innovation (NIBIO)
- Grants-in-Aid for Scientific Research [16K13505, 16H03303, 17H06053] Funding Source: KAKEN
Psychological stresses such as social loss and separation during childhood induce hardship, referred to as emotional pain. These experiences are well-documented risk factors for the development of physical pain in adulthood. However, the underlying neuronal mechanisms of this exacerbation of pain are largely unknown, and consequently there is no effective pharmacotherapy. In this study, we sought to determine whether infant maternal separation (MS) contributes to aggravation of neuropathic pain in adult mice. MS increased anxiety-and depression-like behavioral responses to adult stress. In MS animals, chronic constriction injury (CCI) heightened the sensory dimension of chronic pain relative to that of control mice. However, MS mice treated with fluoxetine for 4 weeks after MS did not exhibit augmentation of allodynia, and their emotional response was attenuated. Microglia were more abundant in the spinal cord in MS/CCI mice than in control/CCI mice. These results suggest that emotional impairment is related to augmentation . of neuropathic pain, and that dysfunction of microglial activation contributes to heightened pain sensitivity.
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