期刊
FEBS LETTERS
卷 589, 期 11, 页码 1257-1265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.03.031
关键词
Exosome; Mesenchymal stem cell; Skeletal muscle; Regeneration; MicroRNA
资金
- MEXT/JSPS KAKENHI [25253089, 24689057]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Grants-in-Aid for Scientific Research [24689057, 25253089] Funding Source: KAKEN
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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