期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ijms17040573
关键词
renal cell cancer-carcinoma; long non-coding RNAs; metastases
资金
- Oesterreichische Nationalbank [15888]
- [PN-II-PT-PCCA-2011-3.1-1221]
- [125/2012]
Renal cell carcinoma (RCC) represents a deadly disease with rising mortality despite intensive therapeutic efforts. It comprises several subtypes in terms of distinct histopathological features and different clinical presentations. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts in the genome which vary in expression levels and length and perform diverse functions. They are involved in the inititation, evolution and progression of primary cancer, as well as in the development and spread of metastases. Recently, several lncRNAs were described in RCC. This review emphasises the rising importance of lncRNAs in RCC. Moreover, it provides an outlook on their therapeutic potential in the future.
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