期刊
FEBS LETTERS
卷 589, 期 4, 页码 500-506出版社
WILEY
DOI: 10.1016/j.febslet.2015.01.009
关键词
Liver cancer stem cell; MiR-155; Tumor Protein 53-Induced Nuclear Protein 1; Tumor sphere; Liver cancer
资金
- Key project of Chongqing Medical Science Foundation [2011-1-055]
- National Natural Science Foundation of China [81101827]
- Science and technology research project by Chongqing Municipal Education Commission [KJ1400214]
- Science and technology planning project by Yuzhong District of Chongqing [20140102]
In liver cancer, miR-155up-regulation can regulate cancer-cell invasion. However, whether miR-155 expression is associated with liver cancer stem cells (CSCs) remains unknown. Here, we show that miR-155 expression is up-regulated in tumor spheres. Knock-down of miR-155 resulted in suppression of tumor sphere formation, through a decrease in the proportion of CD90(+) and CD133(+) CSCs and in the expression of Oct4, whereas miR-155 overexpression had the opposite effect. TP53INP1 was determined to be involved in the CSCs-like properties that were regulated by miR-155. Thus, miR-155 may play an important role in promoting the generation of stem cell-like cells and their selfrenewal by targeting the gene TP53INP1. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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