期刊
NATURE REVIEWS CANCER
卷 16, 期 4, 页码 251-265出版社
NATURE PORTFOLIO
DOI: 10.1038/nrc.2016.15
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资金
- Ludwig Institute for Cancer Research
- Nuffield Department of Medicine
- Development Fund, Oxford Cancer Research Centre, University of Oxford, UK
- National Institute of Environmental Health Sciences, US National Institutes of Health [Z01ES100475, Z01ES46008]
- Office Of The Director
- Office of Integrative Activities [1004057] Funding Source: National Science Foundation
Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.
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