期刊
BASIC RESEARCH IN CARDIOLOGY
卷 113, 期 2, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-018-0670-5
关键词
Cardioprotection; Prosurvival signaling pathways; SAFE pathway; Immune system; Ischemia-reperfusion injury
资金
- Discovery Foundation Fellowship
- University of Cape Town fellowship
- National Research Foundation in South Africa
- Winetech
- AGBL
The survivor activating factor enhancement (SAFE) pathway was discovered as an alternative intrinsic pro-survival signaling pathway to the reperfusion injury salvage kinase pathway for cardioprotection against ischemia-reperfusion injury. The delineation of this pathway, made of key components such as cytokines of the immune system and transcription factors, has brought major advancements in our understanding on how the heart is able to protect itself against ischemia-reperfusion injury. In this viewpoint, we describe the major steps leading to the discovery of the SAFE pathway in small animal models to date and we discuss its translation to large animals and humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据