相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease
Nophar Geifman et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
Peroxiredoxin 6 Is a Crucial Factor in the Initial Step of Mitochondrial Clearance and Is Upstream of the PINK1-Parkin Pathway
Shuaipeng Ma et al.
ANTIOXIDANTS & REDOX SIGNALING (2016)
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
Gian-Luca McLelland et al.
JOURNAL OF CELL BIOLOGY (2016)
SNARE-mediated membrane fusion in autophagy
Yongyao Wang et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
Ruud H. Wijdeven et al.
NATURE COMMUNICATIONS (2016)
Genomics of Alzheimer Disease A Review
Roger N. Rosenberg et al.
JAMA NEUROLOGY (2016)
Cardiolipin Signaling Mechanisms: Collapse of Asymmetry and Oxidation
Valerian E. Kagan et al.
ANTIOXIDANTS & REDOX SIGNALING (2015)
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease
Fathia Djelti et al.
BRAIN (2015)
Secretory autophagy
Marisa Ponpuak et al.
CURRENT OPINION IN CELL BIOLOGY (2015)
Role of cholesterol in SNARE-mediated trafficking on intracellular membranes
Carlos Enrich et al.
JOURNAL OF CELL SCIENCE (2015)
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
Jiajie Diao et al.
NATURE (2015)
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
Beth Levine et al.
TRENDS IN CELL BIOLOGY (2015)
A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity
Shuxi Qiao et al.
NATURE COMMUNICATIONS (2015)
Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking
Elisabet Barbero-Camps et al.
AMERICAN JOURNAL OF PATHOLOGY (2014)
Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival
Juliana Navarro-Yepes et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
A current perspective of autophagosome biogenesis
Shusaku T. Shibutani et al.
CELL RESEARCH (2014)
A new pathway for mitochondrial quality control: mitochondrial-derived vesicles
Ayumu Sugiura et al.
EMBO JOURNAL (2014)
Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
Arnaud Francois et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes
Catherine Marquer et al.
MOLECULAR NEURODEGENERATION (2014)
Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease
Martina Malnar et al.
NEUROBIOLOGY OF DISEASE (2014)
ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells
Y. Ci et al.
CELL DEATH & DISEASE (2014)
Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons
Nguyen-Vi Mohamed et al.
SCIENTIFIC REPORTS (2014)
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients
Adina N. Lazar et al.
ACTA NEUROPATHOLOGICA (2013)
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
Antonella Caccamo et al.
AGING CELL (2013)
Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
Irina Lonskaya et al.
EMBO MOLECULAR MEDICINE (2013)
APP/PS1 mice overexpressing SREBP-2 exhibit combined A accumulation and tau pathology underlying Alzheimers disease
Elisabet Barbero-Camps et al.
HUMAN MOLECULAR GENETICS (2013)
Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
Patrick Ejlerskov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer's Disease Pathogenesis
M. Maulik et al.
MOLECULAR NEUROBIOLOGY (2013)
Autophagosomes form at ER-mitochondria contact sites
Maho Hamasaki et al.
NATURE (2013)
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Charleen T. Chu et al.
NATURE CELL BIOLOGY (2013)
The autophagosome: origins unknown, biogenesis complex
Christopher A. Lamb et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
Sefika Ozcelik et al.
PLOS ONE (2013)
Aβ Secretion and Plaque Formation Depend on Autophagy
Per Nilsson et al.
CELL REPORTS (2013)
Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease
Sovan Sarkar et al.
CELL REPORTS (2013)
Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells
Enrico Desideri et al.
AUTOPHAGY (2012)
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
Yuqing Wang et al.
AUTOPHAGY (2012)
Dual roles of Atg8-PE deconjugation by Atg4 in autophagy
Zhong-Qiu Yu et al.
AUTOPHAGY (2012)
Autophagy in lysosomal storage disorders
Andrew P. Lieberman et al.
AUTOPHAGY (2012)
Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin
Mahua Maulik et al.
HUMAN MOLECULAR GENETICS (2012)
Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels
C. Y. Daniel Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
Katrijn Coen et al.
JOURNAL OF CELL BIOLOGY (2012)
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease
Jiaqi Yao et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
DJ-1 Protects Dopaminergic Neurons against Rotenone-Induced Apoptosis by Enhancing ERK-Dependent Mitophagy
H. Gao et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
Sebastian Alers et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons
Liang Hui et al.
LIFE SCIENCES (2012)
Rab5 is necessary for the biogenesis of the endolysosomal system in vivo
Anja Zeigerer et al.
NATURE (2012)
NIH Image to ImageJ: 25 years of image analysis
Caroline A. Schneider et al.
NATURE METHODS (2012)
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
Ulrike Krueger et al.
NEUROBIOLOGY OF AGING (2012)
Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation
Hanna Appelqvist et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation MECHANISTIC IMPLICATIONS FOR THE INTRINSIC PATHWAY OF OXIDATIVE APOPTOSIS
Witold Korytowski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment
Amal Aqul et al.
JOURNAL OF NEUROSCIENCE (2011)
Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a γ-Secretase-Independent Manner
Kara M. Neely et al.
JOURNAL OF NEUROSCIENCE (2011)
Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function
Meritxell Reverter et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
Smita Majumder et al.
PLOS ONE (2011)
Under the ROS ... Thiol network is the principal suspect for autophagy commitment
Giuseppe Filomeni et al.
AUTOPHAGY (2010)
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee et al.
CELL (2010)
Oxidative Stress and Altered Mitochondrial Function in Neurodegenerative Diseases: Lessons From Mouse Models
J. C. Fernandez-Checa et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders
Alessandro Fraldi et al.
EMBO JOURNAL (2010)
Altered lipid content inhibits autophagic vesicular fusion
Hiroshi Koga et al.
FASEB JOURNAL (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex
Philipp A. Jaeger et al.
PLOS ONE (2010)
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells
Anton I. Rosenbaum et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Midlife Serum Cholesterol and Increased Risk of Alzheimer's and Vascular Dementia Three Decades Later
Alina Solomon et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2009)
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Yipeng Wang et al.
HUMAN MOLECULAR GENETICS (2009)
Neural Cell Adhesion Molecule Modulates Dopaminergic Signaling and Behavior by Regulating Dopamine D2 Receptor Internalization
Mei-Fang Xiao et al.
JOURNAL OF NEUROSCIENCE (2009)
Mitochondrial Cholesterol Loading Exacerbates Amyloid β Peptide-Induced Inflammation and Neurotoxicity
Anna Fernandez et al.
JOURNAL OF NEUROSCIENCE (2009)
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse
Benny Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-κB activation
Montserrat Mari et al.
GASTROENTEROLOGY (2008)
Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production
Huaqi Xiong et al.
NEUROBIOLOGY OF DISEASE (2008)
Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
Komla Sobo et al.
PLOS ONE (2007)
Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npcl-/- mouse brain
Guanghong Liao et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Ruth Scherz-Shouval et al.
EMBO JOURNAL (2007)
Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies
Raphael Zidovetzki et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
Susmita Kaushik et al.
EMBO JOURNAL (2006)
Cholesterol synthesis rate in human hippocampus declines with aging
K. M. Thelen et al.
NEUROSCIENCE LETTERS (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Macroautophagy -: a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu et al.
JOURNAL OF CELL BIOLOGY (2005)
SNARES and traffic
WJ Hong
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Intracellular accumulation of amyloidogenic fragments of amyloid-β precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities
LW Jin et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
RG Cutler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo:: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky et al.
HUMAN MOLECULAR GENETICS (2004)
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
J Heeren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
M Heverin et al.
JOURNAL OF LIPID RESEARCH (2004)
Late endosome motility depends on lipids via the small GTPase Rab7
C Lebrand et al.
EMBO JOURNAL (2002)
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome -: Differential effects of APOE genotype and presenilin mutations
AM Cataldo et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)