期刊
FEBS LETTERS
卷 589, 期 24, 页码 3998-4009出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.11.010
关键词
Homocysteine; Atherosclerosis; Foam cell; Fatty acid-binding protein 4; DNA methylation
资金
- National Natural Science Foundation of China [81160044, 81260105, 81260063, 81360052]
- Ningxia Natural Science Foundation [NZ13054]
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy on fatty acid-binding protein 4 (FABP4), and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased FABP4 expression and decreased methylation. The FABP4 expression and DNA methylation was assessed in the aorta of ApoE(-/-) mice fed high-methionine diet for 20 weeks. Over-expression of FABP4 enhanced accumulation of total cholesterol and cholesterol ester in foam cells. The upregulation of DNA methyltransferase 1 (DNMT1) promoted the methylation process and decreased FABP4 expression. These data suggest that FABP4 plays a key role in Hcy-mediated disturbance of lipid metabolism and that DNMT1 may be a novel therapeutic target in Hcy-related atherosclerosis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据