期刊
AUTOPHAGY
卷 14, 期 6, 页码 1094-1096出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2018.1444314
关键词
CMA; ER stress; p38 MAPK; Parkinson's disease; PERK
类别
资金
- NIH [NS079858, AG023695, NS095269]
- National Natural Science Foundation of China [31371400, 31671060]
- National Institute of Neurological Disorders and Stroke [NS079858]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS095269] Funding Source: NIH RePORTER
Chaperone-mediated autophagy (CMA), a form of selective autophagy, maintains cellular proteostasis in response to diverse stress conditions. Whether and how endoplasmic reticulum (ER) stress triggers CMA remains elusive. In our recent study, we demonstrate that various types of ER stress activate the CMA pathway via an EIF2AK3/PERK-MAP2K4/MKK4-MAPK14/p38-dependent manner. We term this process ERICA for ER stress-induced chaperone-mediated autophagy. This pathway is activated in response to stress associated with Parkinson disease and is required for the viability of the SNc dopaminergic neurons in an animal model of Parkinson disease.
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