期刊
FEBS LETTERS
卷 589, 期 18, 页码 2388-2393出版社
WILEY
DOI: 10.1016/j.febslet.2015.07.010
关键词
Colon cancer; Metastasis; Inflammation; microRNAs; miR-21; RAGE; RECK; AP-1; TCGA
资金
- Michele and Grant Senner Endowment
- ACS/IRG [74-001-34]
S100P signaling through the receptor for advanced glycation end-products (RAGE) contributes to colon cancer invasion and metastasis, but the mechanistic features of this process are obscure. Here, we investigate whether activation of S100P/RAGE signaling regulates oncogenic microRNA-21 (miR-21). We show that exogenous S100P up-regulates miR-21 levels in human colon cancer cells, whereas knockdown of S100P results in a decrease of miR-21. Furthermore, blockage of RAGE with anti-RAGE antibody suppresses S100P induction of miR-21. In addition, we found that S100P induction of miR-21 expression involves ERK and is suppressed by the MEK inhibitor U0126. Also, S100P treatment stimulates the enrichment of c-Fos, and AP-1 family members, at the miR-21 gene promoter. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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