期刊
FEBS LETTERS
卷 589, 期 14, 页码 1546-1551出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.05.008
关键词
Autophagy; Phosphatidylinositol; 3-phosphate; WIPI; WIPI1; WIPI2
资金
- Ministry of Science, Research
- Arts Baden Wuerttemberg (MWK Stuttgart, Landesforschungsschwerpunkt)
- International Research Training Group of the Deutsche Forschungsgesellschaft (DFG) [GRK 1302]
- International Max Planck Research School 'From Molecules to Organisms', Tuebingen, Germany
Despite the availability of a large pool of experimental approaches and hypothetical considerations, the hunt for the enigmatic membrane origin of autophagosomes is still on. In mammalian cells proposed scenarios for the formation of the autophagosomal membrane include both de novo assembly, and rearrangements plus maturation of pre-existing membrane sections from the endoplasmic reticulum (ER), plasma membrane, Golgi or mitochondria. Earlier, we identified the human WD-repeat protein interacting with phosphoinositides (WIPI) family and showed that WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome. Interestingly, WIPI proteins localize to both pre-existing endomembranes and nascent autophagosomes. In this context, and on the basis of historical records on the formation of autophagosomes, we discuss with appropriate modesty an alternative perspective on the membrane origin of autophagosomes. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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