期刊
FEBS LETTERS
卷 589, 期 6, 页码 710-717出版社
WILEY
DOI: 10.1016/j.febslet.2015.01.038
关键词
Preeclampsia; Mesenchymal stem cell; microRNA-494-3p; Vascular endothelial growth factor; Angiogenesis
资金
- National Natural Science Foundation of China [81270713, 31370899, 81401223]
- Key Clinical Medicine Project of Science and Technology Department of Jiangsu Province [BL2014069]
Mesenchymal stem cells (MSCs) play an important role in the pathology of preeclampsia (PE). Our previous microarray analysis found that microRNA-494 (miR-494) is highly expressed in decidua-derived MSCs (dMSCs) from PE. We hypothesized that aberrant expression of miR-494 in dMSCs is involved in PE development. In the present study, we found that miR-494 arrests G1/S transition in dMSCs by targeting CDK6 and CCND1. We also found that supernatant from miR-494-overexpress-ing dMSCs reduces HTR-8/SVneo migration and impairs HUVEC capillary formation by suppressing VEGF. Taken together, we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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