期刊
AUTOIMMUNITY REVIEWS
卷 17, 期 2, 页码 188-194出版社
ELSEVIER
DOI: 10.1016/j.autrev.2017.11.022
关键词
Giant cell arteritis; Biomarkers; Serology; ELISA; Luminex multiarray
类别
资金
- Slovenian Research Agency [P3-0314]
- Austrian Ministry of Science, Research and Economy (HSRSM project OMICS Center Graz)
Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50 years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis. (C) 2017 Elsevier B.V. All rights reserved.
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