期刊
RSC ADVANCES
卷 6, 期 28, 页码 23126-23133出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra26323a
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资金
- Cancer Prevention Research Institute of Texas [RP130604]
- National Institute of Biomedical Imaging and Bioengineering [1R01EB014354-01A1]
- National Cancer Institute [P30-CA016086-35-37]
- Biomedical Research Imaging Center, University of North Carolina at Chapel Hill
- Development and Promotion of Science and Technology (DPST) project under Royal Thai Government
With the goal of developing new positron emission tomography (PET) probes for imaging inflammation in cancer tumours, we have conjugated zwitterionic phosphonium aryltrifluoroborates as fluoride captors with indomethacin, a known cyclooxygenase 2 inhibitor. The resulting conjugates have been radiolabeled by F-18-F-19 isotopic exchange in aqueous solutions. NMR studies combined with in vivo data show that the nature of the phosphonium substituents plays an important role on the stability of the radiotracers.
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