期刊
FEBS LETTERS
卷 589, 期 15, 页码 1966-1974出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.05.036
关键词
DRBD13; Post transcriptional gene regulatory program; Insect stage differentiation process; Trypanosoma brucei
资金
- Canadian Institute of Health Research (CIHR) [119464]
- Le Fonds Quebecois de la recherche sur la nature et les technologies (FQRNT)
- CIHR Systems Biology Fellowship
DRBD13 RNA-binding protein (RBP) regulates the abundance of AU-rich element (ARE)-containing transcripts in trypanosomes. Here we show that DRBD13 regulates RBP6, the developmentally critical protein in trypanosomatids. We also show DRBDI3-specific regulation of transcripts encoding cell surface coat proteins including GPEET2, variable surface glycoprotein (VSG) and invariant surface glycoprotein (ISG). Accordingly, alteration in DRBD13 levels leads to changes in the target mRNA abundance and parasite morphology. The high consistency of the observed phenotype with known cell membrane exchanges that occur during progression of T. brucei through the insect stage of its life cycle suggests that DRBD13 is an important regulator in this largely unknown developmental process. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据