期刊
FEBS LETTERS
卷 589, 期 16, 页码 2034-2042出版社
WILEY
DOI: 10.1016/j.febslet.2015.05.042
关键词
Gastric cancer; Silent mating type information regulation 1; Autophagy; Tumor suppressor; Tumor promoter
资金
- National Natural Science Foundation of China [81270150]
- International Cooperation Project of Science and Technology Research of Shaanxi Province [2012KW-41]
Silent mating type information regulation 1 (SIRT1) is implicated in tumorigenesis through its effect on autophagy. In gastric cancer (GC), SIRT1 is a marker for prognosis and is involved in cell invasion, proliferation, epithelial-mesenchymal transition (EMT) and drug resistance. Autophagy can function as a cell-survival mechanism or lead to cell death during the genesis and treatment of GC. This functionality is determined by factors including the stage of the tumor, cellular context and stress levels. Interestingly, SIRT1 can regulate autophagy through the deacetylation of autophagy-related genes (ATGs) and mediators of autophagy. Taken together, these findings support the need for continued research efforts to understand the mechanisms mediating the development of gastric cancer and unveil new strategies to eradicate this disease. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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