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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models
Robert L. Hudkins et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
Edward D. Plowey et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
Anthony K. F. Liou et al.
NEUROBIOLOGY OF DISEASE (2008)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Patrick A. Lewis et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Leucine-Rich Repeat kinase 2 G238SR variant is a risk factor for Parkinson disease in Asian population
Manabu Funayama et al.
NEUROREPORT (2007)
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2
Maria Hoyer-Hansen et al.
MOLECULAR CELL (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
Identification of potential protein interactors of Lrrk2
Justus C. Daechsel et al.
PARKINSONISM & RELATED DISORDERS (2007)
The Parkinson disease gene LRRK2:: Evolutionary and structural insights
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION (2006)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease:: clinical, pathological, olfactory and functional imaging and genetic data
NL Khan et al.
BRAIN (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Prevalence and incidence of Parkinson's disease in Europe
S von Campenhausen et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2005)
An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family
M Funayama et al.
ANNALS OF NEUROLOGY (2005)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Incidence of Parkinson's disease: Variation by age, gender, and Race/Ethnicity
SK Van Den Eeden et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2003)
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