期刊
FEBS JOURNAL
卷 282, 期 10, 页码 1858-1870出版社
WILEY-BLACKWELL
DOI: 10.1111/febs.13253
关键词
lysosomes; autophagy; apoptosis; necrosis; mTOR
资金
- Cancer Research UK
- Worldwide Cancer Research
- Cancer Research UK [15816] Funding Source: researchfish
Nearly 60 years ago, lysosomes were first described in the laboratory of Christian de Duve, a discovery that significantly contributed to him being awarded a share of the 1974 Nobel Prize in Physiology or Medicine for elucidating 'the structural and functional organization of the cell'. Initially thought of as a simple waste degradation facility of the cell, these organelles recently emerged as signalling centres with connections to major cellular processes. This review provides an overview of the many roles of lysosomal proteins in two of these processes: cell death and autophagy. We discuss both resident lysosomal proteins as well those that temporarily associate with lysosomes to influence autophagy and cell death pathways. Particular focus is given to studies in mammalian cells and in vivo systems.
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