4.6 Review

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment

Todd VanArsdale et al.

CLINICAL CANCER RESEARCH (2015)

Article Cell Biology

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics

Massimo Bogliolo et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2015)

Review Chemistry, Medicinal

Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer

Kevin M. Foote et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Gastroenterology & Hepatology

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Nuria Segui et al.

GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Megan Carter et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

A. Patel et al.

ONCOGENE (2015)

Article Oncology

Therapeutic opportunities within the DNA damage response

Laurence H. Pearl et al.

NATURE REVIEWS CANCER (2015)

Article Multidisciplinary Sciences

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Kilian V. M. Huber et al.

NATURE (2014)

Article Multidisciplinary Sciences

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad et al.

NATURE (2014)

Review Genetics & Heredity

Unravelling the genomic targets of small molecules using high-throughput sequencing

Raphael Rodriguez et al.

NATURE REVIEWS GENETICS (2014)

Article Multidisciplinary Sciences

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

Tim Wang et al.

SCIENCE (2014)

Article Cell Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

Anuja Mehta et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Cell Biology

Oxidative stress and cancer: An overview

Venus Sosa et al.

AGEING RESEARCH REVIEWS (2013)

Article Biochemistry & Molecular Biology

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

Jacqueline H. Barlow et al.

Article Biochemistry & Molecular Biology

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Luis Ignacio Toledo et al.

Review Cell Biology

Wee1 kinase as a target for cancer therapy

Khanh Do et al.

CELL CYCLE (2013)

Review Chemistry, Multidisciplinary

Transcription-Associated Genome Instability

Helene Gaillard et al.

CHEMICAL REVIEWS (2013)

Review Biochemistry & Molecular Biology

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

Kahlin Cheung-Ong et al.

CHEMISTRY & BIOLOGY (2013)

Article Multidisciplinary Sciences

Replication stress links structural and numerical cancer chromosomal instability

Rebecca A. Burrell et al.

NATURE (2013)

Review Multidisciplinary Sciences

The causes and consequences of genetic heterogeneity in cancer evolution

Rebecca A. Burrell et al.

NATURE (2013)

Article Multidisciplinary Sciences

Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth et al.

NATURE (2013)

Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Biochemistry & Molecular Biology

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

Jordi Carreras Puigvert et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

Anitha Suram et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates COMPARISON WITH MTH1 AND MTH2

Yasumitsu Takagi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Cell Biology

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

Julian E. Sale et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Medicine, General & Internal

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cisplatin resistance

L. Galluzzi et al.

ONCOGENE (2012)

Review Oncology

DNA repair dysregulation from cancer driver to therapeutic target

Nicola J. Curtin

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

Assaf C. Bester et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Oncology

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Andreas Hoeglund et al.

CLINICAL CANCER RESEARCH (2011)

Review Genetics & Heredity

The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality

Hanspeter Naegeli et al.

DNA REPAIR (2011)

Article Biochemistry & Molecular Biology

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

Linda M. Svensson et al.

FEBS LETTERS (2011)

Article Biochemistry & Molecular Biology

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Matilde Murga et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Luis I. Toledo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Pharmacology & Pharmacy

Oxidative stress and oxidative damage in chemical carcinogenesis

James E. Klaunig et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)

Review Biochemistry & Molecular Biology

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

Cynthia X. Ma et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Article Biochemistry & Molecular Biology

Temozolomide: Mechanisms of Action, Repair and Resistance

Jihong Zhang et al.

Current Molecular Pharmacology (2011)

Review Oncology

DNA polymerases and cancer

Sabine S. Lange et al.

NATURE REVIEWS CANCER (2011)

Article Biotechnology & Applied Microbiology

Mechanisms of dealing with DNA damage in terminally differentiated cells

P. Fortini et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)

Article Multidisciplinary Sciences

Chk1 promotes replication fork progression by controlling replication initiation

Eva Petermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Y-family DNA polymerases in mammalian cells

Caixia Guo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Cell Biology

Eukaryotic DNA replication control: Lock and load, then fire

Dirk Remus et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

Renee D. Paulsen et al.

MOLECULAR CELL (2009)

Review Oncology

Role of mismatch repair and MGMT in response to anticancer therapies

Ida Casorelli et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)

Review Cell Biology

ATR: an essential regulator of genome integrity

Karlene A. Cimprich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

Deborah Wilsker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Multidisciplinary Sciences

An oncogene-induced DNA damage model for cancer development

Thanos D. Halazonetis et al.

SCIENCE (2008)

Article Biochemical Research Methods

High-content fluorescent-based assay for screening activators of DNA damage checkpoint pathways

Bin Zhang et al.

JOURNAL OF BIOMOLECULAR SCREENING (2008)

Article Biochemistry & Molecular Biology

Transcription-associated recombination is dependent on replication in mammalian cells

Ponnari Gottipati et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Cell Biology

Regulation of DNA double-strand break repair pathway choice

Meena Shrivastav et al.

CELL RESEARCH (2008)

Review Oncology

DNA repair pathways as targets for cancer therapy

Thomas Helleday et al.

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Nadine K. Kolas et al.

SCIENCE (2007)

Article Chemistry, Multidisciplinary

Understanding ribonucleotide reductase inactivation by gemcitabine

Nuno M. F. S. A. Cerqueira et al.

CHEMISTRY-A EUROPEAN JOURNAL (2007)

Article Oncology

Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway

D Chirnomas et al.

MOLECULAR CANCER THERAPEUTICS (2006)

Review Cell Biology

Is base excision repair a tumor suppressor mechanism?

JB Sweasy et al.

CELL CYCLE (2006)

Article Oncology

Targeted modulation of MGMT: Clinical implications

LL Liu et al.

CLINICAL CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells

C Morales et al.

ONCOGENE (2005)

Article Multidisciplinary Sciences

Recruitment of DNA methyltransferase I to DNA repair sites

O Mortusewicz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

Telomere erosion and chromosomal instability in cells expressing the HPV oncogene 16E6

AW Plug-DeMaggio et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

Visualization of altered replication dynamics after DNA damage in human cells

CJ Merrick et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Cisplatin: mode of cytotoxic action and molecular basis of resistance

ZH Siddik

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides

JP Cai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Multidisciplinary Sciences

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

K Rothkamm et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Immunology

Defective DNA repair and increased genomic instability in artemis-deficient murine cells

S Rooney et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Hematology

Cancer incidence in persons with Fanconi anemia

PS Rosenberg et al.

Article Biochemistry & Molecular Biology

ATR regulates fragile site stability

AM Casper et al.

Article Biochemistry & Molecular Biology

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells

C Lundin et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Deficiency in BRCA2 leads to increase in non-conservative homologous recombination

F Larminat et al.

ONCOGENE (2002)

Review Biochemistry & Molecular Biology

The connection between transcription and genomic instability

A Aguilera

EMBO JOURNAL (2002)

Review Multidisciplinary Sciences

Genome maintenance mechanisms for preventing cancer

JHJ Hoeijmakers

NATURE (2001)

Article Biochemistry & Molecular Biology

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DMA replication checkpoint

M Hekmat-Nejad et al.

CURRENT BIOLOGY (2000)

Article Oncology

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

M Esteller et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)