期刊
FEBS JOURNAL
卷 282, 期 17, 页码 3275-3285出版社
WILEY-BLACKWELL
DOI: 10.1111/febs.13323
关键词
gene expression; Hog1; mammals; osmostress; p38; SAPK; stress responses; yeast
资金
- Spanish Ministry of Economy and Competitiveness (FEDER) [BFU2012-33503, BFU2014-52125-REDT, BFU2014-51672-REDC, BFU2014-52333-P]
- Catalan Government [SGR 599]
- ERC [294294]
- Fundacion Botin
- Banco Santander through Santander Universities Global Division
- ICREA Academia (Generalitat de Catalunya)
- European Research Council (ERC) [294294] Funding Source: European Research Council (ERC)
Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.
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