期刊
VETERINARY RESEARCH
卷 47, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13567-016-0332-2
关键词
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资金
- Chinese National Science Foundation [31472172]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Natural Science Foundation from Chongqing [cstc2014jcyjA1628]
- Jiangsu province [14KJA230001, BE2014358]
- Ministry of Agriculture of the People's Republic of China [2011-G24]
The levels of cellular reactive oxygen species (ROS) and ATP as well as the mitochondrial membrane potential (MMP) in response to bovine herpesvirus 1 (BHV-1) infection of MDBK cells were measured, respectively. BHV-1 infection increased ROS production which depended on viral entry, and de novo protein expression and/or DNA replication. Vice versa, excessive ROS was required for efficient viral replication. Levels of both ATP and MMP were significantly decreased after BHV-1 infection. Interestingly, the loss of MMP was ameliorated by ROS depression. Collectively, ROS dependent mitochondrial damage and ultimately disruption of energy metabolism (ATP depletion) are a potential pathogenic mechanism for BHV-1 infection.
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