期刊
FEBS JOURNAL
卷 283, 期 14, 页码 2616-2625出版社
WILEY-BLACKWELL
DOI: 10.1111/febs.13520
关键词
apoptosis; caspase-8; MLKL; necroptosis; RIPK1; RIPK3
资金
- NCI NIH HHS [R21 CA185681] Funding Source: Medline
- NIAID NIH HHS [R01 AI108685] Funding Source: Medline
Necroptosis is a form of programmed cell death that is both mechanistically and morphologically distinct from apoptosis, the canonical mechanism of cell suicide. Although early descriptions of necroptosis date back decades, the last 5 years have seen a proliferation of studies of this process. This surge in interest has included the recent publication of several excellent, in-depth reviews of the literature [Chan FK-M et al. (2014) Annu Rev Immunol 33, 141210135520002; Weinlich R & Green DR (2014) Mol Cell 56, 469-480; Silke J et al. (2015) Nat Immunol 16, 689-697; Linkermann A & Green DR (2014) N Engl J Med 370, 455-465]. Rather than contribute another summary to this well-summarized field, in this Minireview I will briefly discuss key recent findings, then touch on some of the major outstanding questions -the known unknowns - that remain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据