期刊
ASIAN JOURNAL OF ANDROLOGY
卷 21, 期 3, 页码 224-232出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/aja.aja_38_18
关键词
B lymphoma Moloney murine leukemia virus insertion region 1; oncogene; polycomb repressive complex 1; prostate cancer
资金
- Houston Methodist Research Institute
- Prostate Cancer Foundation [13YOUN007]
- U.S. Department of Defense [W81XWH-15-1-0639, W81XWH-17-1-0357]
- American Cancer Society [TBE-128382]
- NIH/NCI [1R01CA208257]
B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial-mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation. Importantly, overexpression of BMI1 is predictive for drug resistance, tumor recurrence, and eventual therapy failure of various cancer subtypes, which renders the pharmacological targeting at BMI1 as a novel and promising therapeutic approach. The study on prostate cancer, a prevalent hormone-related cancer among men, has promoted enormous research advancements in cancer genetics and epigenetics. This review summarizes the role of BMI1 as an oncogenic and epigenetic regulator in tumor initiation, progression, and relapse of prostate cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据