期刊
FASEB JOURNAL
卷 29, 期 8, 页码 3263-3273出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.15-271700
关键词
IL-10; neutrophil; microbiota
资金
- Natural Basic Research Program of China [2011CB711000, 2010CB945300]
- National Natural Science Foundation of China [31270935, 81471525, 31171144, 81272177]
- Beijing Natural Science Foundation [5152010]
- State Key Laboratory Grant of Space Medicine Fundamentals and Application [SMFA10A01]
The immune systems can be altered by spaceflight in many aspects, but microgravity-related mucosal immune changes and its clinical significance have not been well studied. The purpose of this study was to investigate whether simulated microgravity influences the intestinal homeostasis and increases the susceptibility to colon inflammation. The hindlimb unloading (HU) mouse model was used to simulate the microgravity condition. Three percent dextran sulfate sodium (DSS) was given to mice to induce colitis. Compared to ground control (Ctrl) mice, the HU ones revealed an impaired intestinal homeostasis and increased susceptibility to DSS-induced colitis. This includes an early-onset, 4-fold expansion of segmented filamentous bacteria (SFB), more than 2-fold decrease in regulatory T (T-reg) cell numbers and IL-10 production, similar to 2-fold increase in colonic IL-1 beta expression, 2-fold increase in circulating neutrophils, and colonic neutrophil infiltration. The application of antibiotics ameliorated the T-reg and IL-10 reductions but did not significantly dampen neutrophilia and elevated expression of colonic IL-1 beta. These results indicate that the intestinal microflora and innate immune system both respond to simulated microgravity and together, contribute to the proinflammatory shift in the gut microenvironment. The data also emphasize the necessity for evaluating the susceptibility to inflammatory bowel diseases (IBDs) in distant space travels.
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