期刊
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
卷 23, 期 1, 页码 -出版社
EDP SCIENCES S A
DOI: 10.1051/ocl/2015061
关键词
AceDoPC (R); acetyl-LysoPC-DHA; blood-brain barrier; carrier
类别
资金
- Polaris
- ANR
- Ministry of Research
- LISA Carnot institute
AceDoPCr (R) is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPCr (R) allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPCr (R) is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPCr (R) prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPCr (R) a promising phospholipid carrier of DHA to the brain.
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