Lymphoproliferative Disorders of the Gastrointestinal Tract

Context.-The diagnosis of gastrointestinal lymphoproliferative disorders can be challenging because of the small size of biopsies and the wide spectrum of lymphoproliferative disorders that may be encountered. Objective.-To review the spectrum of lymphoproliferative disorders involving the gastrointestinal tract, highlighting potential pitfalls. Data Sources.-Peer-reviewed articles and clinical experience. Conclusions.-Interpretation of lymphoid infiltrates in gastrointestinal biopsies requires synthesis of morphologic, immunophenotypic, molecular genetic, and clinical information. Knowledge of indolent lymphoproliferative disorders that may mimic aggressive lymphomas will help in preventing misdiagnoses.