期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 57, 期 2, 页码 617-625出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.15-18133
关键词
dry eye; aesthesiometer; mechanical thresholds; ocular pain
资金
- NEI NIH HHS [P30 EY014801, P30EY014801] Funding Source: Medline
- NIDCR NIH HHS [R01 DE022903, NIH NIDCR RO1 DE022903] Funding Source: Medline
- CSRD VA [I01 CX001089] Funding Source: Medline
PURPOSE. To examine associations between corneal mechanical thresholds and metrics of dry eye. METHODS. This was a cross-sectional study of individuals seen in the Miami Veterans Affairs eye clinic. The evaluation consisted of questionnaires regarding dry eye symptoms and ocular pain, corneal mechanical detection and pain thresholds, and a comprehensive ocular surface examination. The main outcome measures were correlations between corneal thresholds and signs and symptoms of dry eye and ocular pain. RESULTS. A total of 129 subjects participated in the study (mean age 64 +/- 10 years). Mechanical detection and pain thresholds on the cornea correlated with age (Spearman's rho = 0.26, 0.23, respectively; both P < 0.05), implying decreased corneal sensitivity with age. Dry eye symptom severity scores and Neuropathic Pain Symptom Inventory (modified for the eye) scores negatively correlated with corneal detection and pain thresholds (range, r = -0.13 to -0.27, P < 0.05 for values between -0.18 and -0.27), suggesting increased corneal sensitivity in those with more severe ocular complaints. Ocular signs, on the other hand, correlated poorly and nonsignificantly with mechanical detection and pain thresholds on the cornea. A multivariable linear regression model found that both posttraumatic stress disorder (PTSD) score (beta = 0.21, SE = 0.03) and corneal pain threshold (beta = -0.03, SE = 0.01) were significantly associated with self-reported evoked eye pain (pain to wind, light, temperature) and explained approximately 32% of measurement variability (R = 0.57). CONCLUSIONS. Mechanical detection and pain thresholds measured on the cornea are correlated with dry eye symptoms and ocular pain. This suggests hypersensitivity within the corneal somatosensory pathways in patients with greater dry eye and ocular pain complaints.
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