期刊
ARCHIVES OF DERMATOLOGICAL RESEARCH
卷 310, 期 5, 页码 391-399出版社
SPRINGER
DOI: 10.1007/s00403-018-1826-8
关键词
Androgenetic alopecia; Androgen; Androgen receptor; Dihydrotestosterone; Dermal papilla; Wnt; beta-catenin
类别
资金
- Junior Research Fellowship by the Council of Scientific and Industrial Research, New Delhi, India [09/844(0045)/2017-EMR-1]
Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5 alpha-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/beta-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia. Here, we analyse the androgen-induced dermal papilla secreted factors on stimulating catagen entry in hair follicles and the molecular cross-talk between AR and Wnt/beta-catenin signaling with a brief mention on alternative treatment strategy targeting Wnt/beta-catenin signaling for promoting hair growth.
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