期刊
WIENER MEDIZINISCHE WOCHENSCHRIFT
卷 166, 期 7-8, 页码 196-204出版社
SPRINGER WIEN
DOI: 10.1007/s10354-016-0432-7
关键词
Endocytosis; Clathrin-mediated endocytosis; Caveolae-mediated endocytosis; Clathrin-independent endocytosis; Endosomes; Endocytic trafficking; Rabs; Rab proteins; Phosphatidylinositol phospholipids; Multivesicular bodies; Clathrin-dependent endocytosis
资金
- NCATS NIH HHS [UL1 TR001105, TL1 TR001104] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007062, R01 GM073165] Funding Source: Medline
- NIMH NIH HHS [R01 MH061345] Funding Source: Medline
This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of the recently discovered early and late endosomes and the mechanisms governing endosomal acidification. As described in this review, after uptake through one of many mechanistically distinct endocytic pathways, internalized proteins merge into a common early/sorting endosome. From there they again diverge along distinct sorting pathways, back to the cell surface, on to the trans-Golgi network or across polarized cells. Other transmembrane receptors are packaged into intraluminal vesicles of late endosomes/multivesicular bodies that eventually fuse with and deliver their content to lysosomes for degradation. Endosomal acidification, in part, determines sorting along this pathway. We describe other sorting machinery and mechanisms, as well as the rab proteins and phosphatidylinositol lipids that serve to dynamically define membrane compartments along the endocytic pathway.
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