期刊
PAIN MANAGEMENT
卷 6, 期 3, 页码 265-284出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pmt.16.4
关键词
cytokines; glia cells; inflammation; nerve injury markers; neuropeptides; pain; prostaglandins; rheumatoid arthritis; TLR4
资金
- Swedish Research Council
- Swedish Foundation for Strategic Research
- Ragnar Soderberg Foundation
- William K Bowes Foundation
- Knut and Alice Wallenberg Foundation
- Karolinska Institutet Foundations
- Konung Gustaf V's Jubilee Foundation
Pain is one of the most challenging symptoms for patients with rheumatoid arthritis ( RA). RA-related pain is frequently considered to be solely a consequence of inflammation in the joints; however, recent studies show that multiple mechanisms are involved. Indeed, RA pain may start even before the disease manifests, and frequently does not correlate with the degree of inflammation or pharmacological management. In this aspect, animal studies have the potential to provide new insights into the pathology that initiate and maintain pain in RA. The focus of this review is to describe the most commonly used animal models for studies of RA pathology, which have also been utilized in pain research, and to summarize findings providing potential clues to the mechanisms involved in the regulation of RA-induced pain.
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