期刊
NATURE REVIEWS CANCER
卷 16, 期 5, 页码 288-304出版社
NATURE PORTFOLIO
DOI: 10.1038/nrc.2016.27
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资金
- US National Institutes of Health [R01 CA140456, R01 CA184624, R01 DK098057, R01 CA154916, RO1 HL119439, PO1 CA165997]
The past several years have seen dramatic leaps in our understanding of how gene expression is rewired at the translation level during tumorigenesis to support the transformed phenotype. This work has been driven by an explosion in technological advances and is revealing previously unimagined regulatory mechanisms that dictate functional expression of the cancer genome. In this Review we discuss emerging trends and exciting new discoveries that reveal how this translational circuitry contributes to specific aspects of tumorigenesis and cancer cell function, with a particular focus on recent insights into the role of translational control in the adaptive response to oncogenic stress conditions.
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