期刊
BREAST CANCER RESEARCH
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13058-016-0701-9
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资金
- Genesis Breast Cancer Prevention [R116883]
- Medical Research Council UK [G1001398]
- Medical Research Council [G1001398] Funding Source: researchfish
- MRC [G1001398] Funding Source: UKRI
High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties of high X-ray density soft tissues, and the causative mechanisms resulting in different mammographic densities, are not well described. Moreover, it is not known how high breast density leads to increased susceptibility for cancer, or the extent to which it causes the genomic changes that characterise the disease. An understanding of these principals may lead to new diagnostic tools and therapeutic interventions.
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