期刊
APPLIED SURFACE SCIENCE
卷 436, 期 -, 页码 653-661出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2017.12.027
关键词
Ion exchange; Layered titanate; Bioactive ions; Osteogenesis; Nanotopography
类别
资金
- Shenzhen Science and Technology Research Funding [JSGG20151030140325149, JCYJ20150630114942256, JCYJ20160531171344016, JCYJ20170413161800287]
- Chinese Postdoctoral Science Foundation [2017M612761]
- National Natural Science Foundation [31700835]
- Guangdong Provincial Science and Technology Project [2017A010103014]
- Shenzhen Peacock Innovation Team grant [110811003586331]
In this study, an osteogenic environment was constructed on Ti alloy implants by in-situ formation of nanosized fibrous titanate, Na2Ti6O13, loaded with bioactive ions, i.e. Sr, Mg and Zn, to enhance surface bioactivity. The bioactive ions were loaded by ion exchange with sodium located at inter-layer positions between the TiO6 slabs, and their release was not associated with the degradation of the structural unit of the titanate. In-vitro cell culture experiments using MC3T3-E1 cells proved that both bioactive ions and nanotopographic features are critical in promoting osteogenic differentiation of the cells. It was found that the osteogenic functions of the titanate can be modulated by the type and amount of ions incorporated. This study points out that nanosized fibrous titanate formed on the Ti alloy can be a promising reservoir for bioactive ions. The major advantage of this approach over other alternatives for bioactive ion delivery using degradable bioceramic coatings is its capacity of maintaining the structural integrity of the coating and thus avoiding structural deterioration and potential mechanical failure. (C) 2017 Elsevier B.V. All rights reserved.
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