期刊
APPLIED PHYSICS B-LASERS AND OPTICS
卷 124, 期 5, 页码 -出版社
SPRINGER
DOI: 10.1007/s00340-018-6946-5
关键词
-
资金
- National Science Foundation [EEC-0540832]
An integrating sphere is used to enhance the collection of backscattered light in a noninvasive glucose sensor based on quantum cascade laser spectroscopy. The sphere enhances signal stability by roughly an order of magnitude, allowing us to use a thermoelectrically (TE) cooled detector while maintaining comparable glucose prediction accuracy levels. Using a smaller TE-cooled detector reduces form factor, creating a mobile sensor. Principal component analysis has predicted principal components of spectra taken from human subjects that closely match the absorption peaks of glucose. These principal components are used as regressors in a linear regression algorithm to make glucose concentration predictions, over 75% of which are clinically accurate.
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