期刊
BIOMEDICAL REPORTS
卷 4, 期 5, 页码 515-518出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2016.625
关键词
nicotinic acetylcholine receptor; cancer; tobacco
Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as nicotine. In recent years, genome-wide association studies have indicated that allelic variation in the alpha 5-alpha 3-beta 4 nAChR cluster on chromosome 15q24-15q25.1 is associated with lung cancer risk. The role of nAChRs in other types of cancer has also been reported. The present review highlights the role of nAChRs in types of human cancer.
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